Patients switching from separate tablets of dapagliflozin (10 mg total daily dose) and metformin to Xigduo should receive the same daily dose of dapagliflozin and metformin already being taken or the nearest therapeutically appropriate dose of metformin.Ī GFR should be assessed before initiation of treatment with metformin containing medicinal products and at least annually thereafter. When Xigduo is used in combination with insulin or an insulin secretagogue such as sulphonylurea, a lower dose of insulin or sulphonylurea may be considered to reduce the risk of hypoglycaemia (see sections 4.5 and 4.8).įor patients switching from separate tablets of dapagliflozin and metformin Patients insufficiently controlled on metformin alone or in combination with other medicinal products for the treatment of diabetes should receive a total daily dose of Xigduo equivalent to dapagliflozin 10 mg, plus the total daily dose of metformin, or the nearest therapeutically appropriate dose, already being taken. Each tablet contains a fixed dose of dapagliflozin and metformin (see section 2).įor patients insufficiently controlled on metformin monotherapy or metformin in combination with other medicinal products for the treatment of diabetes The recommended dose is one tablet twice daily. Adults with normal renal function (glomerular filtration rate ≥ 90 mL/min)
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